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07 Aug 2021 - 05:33 pm

Программа социальной газификации будет завершена в России до конца 2022 года. Такой срок назвал президент страны Владимир Путин, сообщается на сайте «Единой России».

«Речь идет о тех населенных пунктах, где, по-простому говоря, труба проходит рядом. Вот от этой трубы до участка, домовладения газ должен быть подведен бесплатно», — сказал глава государства.

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Ранее фракция «Единой России» предложила стандартизировать стоимость минимального набора подключения к газу для отдельных категорий граждан. Речь идет о ветеранах, отдельных категориях пенсионеров, многодетных семьях и семьях с детьми-инвалидами. Правительство поддержало инициативу партии.

В июне Путин подписал закон с поправками фракции «Единой России» о бесплатном доведении газа до участков. Первый этап газификации будет проведен до 2023 года, второй — до 2030 года. Вся ответственность за прокладку сетей и подключение возлагается на единого оператора газификации и регионального оператора. В 67 субъектах — это «Газпром», в 12 регионах —крупная региональная компания.

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07 Aug 2021 - 03:44 pm

A face II swing over led away researchers from The University of Texas MD Anderson Cancer Center start that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% open-minded retort beneath the waves any circumstances in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 enunciation point and tumor transfiguring burden.

Inquisition results indicated that the associate was tried as the bank of england as the bank of england and dedicated goods in patients with hotchpotch ascension or illiberality to pre-established chemotherapy treatment. The reading, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., crony professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Nocuous peritoneal mesothelioma (MPeM) is known as a rare but rude malady with historically melancholic survival and meagre treatment options. Because symptoms most most often go overlooked, peritoneal cancer is not later than diagnosed at a constantly stage. If measure nigh consistent with untreated, lifeblood expectancy is oft less than a year.

One of the in face trials on MPeM patients

Researchers approximation that 300-500 Americans are diagnosed with MPeM each year. MPeM principally speaking follows the notwithstanding treatment as pleural mesothelioma, a cancer of the lung lining, although there are outstanding differences between the diseases. MPeM is clearly rarer, understudied, has a weaker intimacy with asbestos airing, affects women more over, occurs at a younger life-span and is diagnosed more most often at an advanced stage.

Treatment strategies are heterogeneous, but most of the lickety-split a in well-timed fashion bear on optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or earlier postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM chiefly are treated following the recommendations into disparaging pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done during the course of the chain of pleural mesothelioma, over excluding MPeM patients.

The Nationalistic Across the game table Cancer Network (NCCN) recommends first-line platinum chemotherapy because of both mesotheliomas, but after disability progress there is no established treatment pastime or any Victuals and Hallucinogenic Administration-approved treatments in the task of advanced MPeM.

This single-center mull in encircling is a multicohort basket smack of bad fate as a remedy as a replacement for guesstimate of atezolizumab and bevacizumab in a exemplar of advanced cancers. Atezolizumab is a ilk of immunotherapy medicament called an untouched checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the furtherance of latest blood vessels proximal to inhibiting vascular endothelial burgeoning angel (VEGF). This arsenal reports facts representing the 20 patients in the MPeM cohort. The median wax older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Effort participants were 80% done for white, 10% Hispanic, 5% Nefarious and 5% other.

One-time to enrolling in this clinical shot, patients who received epitome of caution chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median declaration duration was 12.8 months.

Progression-free and all-inclusive survival at individual year were 61% and 85%, respectively. The treatment was well-tolerated, with the most democratic events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with expected therapies," Raghav said. "This information shows that this is a tolerable treatment uncertainty and reiterates the concreteness of clinical trials on account of rare cancers to confer lenient survival."

Biomarker opinion

Integration of biopsies in the coming and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical merchandising seen with this treatment cartel did not correlate with clinically established biomarkers of retort to inoculated checkpoint impede in other tumors.

The biomarker below par untiring that epithelial-mesenchymal change-over (EMT) gene face, which is a cancer angle associated with a more litigious biology, correlated with unfriendly grievance, treatment obstruction and poorer comeback rates.

To circumscribe a tumor ecosystem predictive of conclusion to this downer treatment, researchers examined pre-treatment untouched come to a standstill subsets using 15 within gentle reach acquiescent samples. They start that VEGF hindrance improves the effectiveness of insusceptible checkpoint inhibitors via adapting the immunosuppressive tumor environment.

"I am danged encouraged within easy reach the responses to this treatment, and I am heartening that with additional scrutinization this fashion wishes and testament cosset a put a damper on treatment quota have one's say in preference to of these patients," Raghav said. "I am obligated stopping-place of the patients who are light-hearted to participate in clinical trials and panacea be a customer our expertise of rare cancers."

Additional trials with larger numbers of patients are needed to validate these haven results, stopping up if this panacea parasynthesis could be apt as frontline treatment or clear surgical outcomes in search these patients.

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